Details

Autor(en) / Beteiligte

• Obadia, Laetitia
• Rouillon, Thierry
• Bujoli, Bruno
• Daculsi, Guy
• Bouler, Jean Michel

Titel

Calcium-deficient apatite synthesized by ammonia hydrolysis of dicalcium phosphate dihydrate: Influence of temperature, time, and pressure

Ist Teil von

• Journal of biomedical materials research. Part B, Applied biomaterials, 2007-01, Vol.80B (1), p.32-42

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2007

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• In this work, calcium‐deficient apatites (CDA) were synthesized by ammonia hydrolysis reaction of dicalcium phosphate dihydrate (DCPD; CaHPO4·2H2O) to obtain biphasic calcium phosphates (BCP) without any extraionic substitution. The influence of three parameters was studied: temperature of the reaction (70 and 100°C), time of the reaction (4 and 18 h), and the pressure (open and closed system). Experiments were made according to a factorial design method (FDM) allowing optimization of the number of samples as well as statistical analysis of results. Moreover, the influence of temperature (until 200°C) was investigated. The crystal size of CDA was determined according to the Scherrer's formula and from Rietveld refinements taking the CDA anisotropy into account. The last method seems to be a reliable method to determine crystallite sizes of CDA, since crystallite sizes of CDA along and directions were accessible. The results describe the hydroxyapatite % (HA%) in BCP by a first‐order polynomial equation in the experimental area studied and the HA content was found to increase by raising time and temperature of the reaction. Moreover, the type of reaction system (open/closed vessel) appeared to have little influence on HA%. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007