AIDS (London), 2007-05, Vol.21 (8), p.1043-1045
2007
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- Autor(en) / Beteiligte
- Titel
- Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)
- Ist Teil von
- AIDS (London), 2007-05, Vol.21 (8), p.1043-1045
- Ort / Verlag
- Hagerstown, MD: Lippincott Williams & Wilkins
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0269-9370eISSN: 1473-5571DOI: 10.1097/QAD.0b013e3280d5a7acTitel-ID: cdi_hal_primary_oai_HAL_hal_00166186v1
- Format
- –
- Schlagworte
- AIDS/HIV, Biological and medical sciences, CD4-Positive T-Lymphocytes, CD4-Positive T-Lymphocytes - virology, Cells, Cultured, Gene Products, env, Gene Products, env - genetics, HIV Infections, HIV Infections - immunology, HIV Infections - virology, HIV-1, HIV-1 - genetics, HIV-1 - pathogenicity, HIV-1 - physiology, Human immunodeficiency virus 1, Human viral diseases, Humans, Immunodeficiencies, Immunodeficiencies. Immunoglobulinopathies, Immunopathology, Infectious diseases, Life Sciences, Medical sciences, Microbiology and Parasitology, Phylogeny, Viral diseases, Viral diseases of the lymphoid tissue and the blood. Aids, Viremia, Viremia - virology, Virus Replication