Prion, 2007-01, Vol.1 (1), p.21-25
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Tau Aggregation in Alzheimer's Disease: What Role for Phosphorylation?
- Ist Teil von
- Prion, 2007-01, Vol.1 (1), p.21-25
- Ort / Verlag
- United States: Taylor & Francis
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The crucial role of the neuronal Tau protein in microtubule stabilization and axonal transport suggests that too little or too much Tau might lead to neuronal dysfunction. The presence of a hyper-phosphorylated but non-aggregated molecule as a toxic species that might sequester normal Tau is discussed. We present recent in vitro results that might allow to dissect the role of individual phosphorylation sites on its structure and function. We also discuss in this review the role of phosphorylation for the aggregation of the neuronal Tau protein, and compare it to the aggregation induced by external poly-anions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1933-6896eISSN: 1933-690XDOI: 10.4161/pri.1.1.4055Titel-ID: cdi_hal_primary_oai_HAL_hal_00161158v1
- Format
- –
- Schlagworte
- Alzheimer Disease - metabolism, Alzheimer Disease - pathology, Animals, Axons - metabolism, Axons - pathology, Binding, Biochemistry, Molecular Biology, Biology, Biophysics, Bioscience, Calcium, Cancer, Cell, Cycle, Humans, Landes, Life Sciences, Microtubules - chemistry, Microtubules - metabolism, Mini-Review, Organogenesis, Phosphorylation, Protein Structure, Quaternary, Protein Transport, Proteins, Structural Biology, Structure-Activity Relationship, tau Proteins - chemistry, tau Proteins - metabolism