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Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis
Ist Teil von
The Journal of biological chemistry, 2003-01, Vol.278 (4), p.2461-2468
Ort / Verlag
United States: American Society for Biochemistry and Molecular Biology
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and
insulin sensitivity. In this study, we analyzed globular domain adiponectin (gAd) transgenic (Tg) mice crossed with leptin-deficient
ob/ob or apoE-deficient mice. Interestingly, despite an unexpected similar body weight, gAd Tg ob/ob mice showed amelioration
of insulin resistance and β-cell degranulation as well as diabetes, indicating that globular adiponectin and leptin appeared
to have both distinct and overlapping functions. Amelioration of diabetes and insulin resistance was associated with increased
expression of molecules involved in fatty acid oxidation such as acyl-CoA oxidase, and molecules involved in energy dissipation
such as uncoupling proteins 2 and 3 and increased fatty acid oxidation in skeletal muscle of gAd Tg ob/ob mice. Moreover,
despite similar plasma glucose and lipid levels on an apoE-deficient background, gAd Tg apoE-deficient mice showed amelioration
of atherosclerosis, which was associated with decreased expression of class A scavenger receptor and tumor necrosis factor
α. This is the first demonstration that globular adiponectin can protect against atherosclerosis in vivo . In conclusion, replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and
atherosclerosis.