Details

Autor(en) / Beteiligte

• Tabcheh, Mohamad
• Baroudi, Moomen
• Elomar, Fawaz
• Elzant, Amer
• Elkhatib, Mazen
• Rolland, Valérie

Titel

New Imidazole Compounds Derived from Pyrrolidonic and Piperidonic Acids as NON-Steroidic Aromatase Inhibitors

Ist Teil von

• Asian journal of chemistry, 2006, Vol.18 (3), p.1771-1782

Ort / Verlag

ASIAN PUBLICATION CORPORATION

Erscheinungsjahr

2006

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Imidazole and indole compounds derived from pyrrolidine and piperidine carboxylic acids are synthesized and characterized. The inhibition activity of those compounds was evaluated in-vitro on aromatase extracted from human placenta, compared to the first representative non-steroid agent (aminoglutethimide). Imidazoles derivatives showed significant inhibition of aromatase (Ki < 78.0 mM).