Details

Autor(en) / Beteiligte

• Sarges, Kevin Matheus Lima de
• Póvoa da Costa, Flávia
• Santos, Erika Ferreira dos
• Cantanhede, Marcos Henrique Damasceno
• da Silva, Rosilene
• Veríssimo, Adriana de Oliveira Lameira
• Viana, Maria de Nazaré do Socorro de Almeida
• Rodrigues, Fabíola Brasil Barbosa
• Leite, Mauro de Meira
• Torres, Maria Karoliny da Silva
• Bentes da Silva, Christiane
• Brito, Mioni Thieli Figueiredo Magalhães de
• Silva, Andréa Luciana Soares da
• Henriques, Daniele Freitas
• Vallinoto, Izaura Maria Vieira Cayres
• Viana, Giselle Maria Rachid
• Queiroz, Maria Alice Freitas
• Vallinoto, Antonio Carlos Rosário
• Santos, Eduardo José Melo dos

Titel

Association of the IIFNG/I +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility

Ist Teil von

• Viruses, 2024-04, Vol.16 (4)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2024

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere (n = 150) and severe (n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.