Details

Autor(en) / Beteiligte

• Compagno, Nicola
• Piccolo, Rachele
• Bortolamiol, Enrica
• Demitri, Nicola
• Rizzolio, Flavio
• Visentin, Fabiano
• Scattolin, Thomas

Titel

Platinumditosylethene Complexes Bearing Phosphine, Isocyanide and IN/I-Heterocyclic Carbene Ligands: Synthesis and Cytotoxicity towards Ovarian and Breast Cancer Cells

Ist Teil von

• Molecules (Basel, Switzerland), 2024-03, Vol.29 (5)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2024

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A wide range of platinum(0)-η[sup.2]-(E)-1,2-ditosylethene complexes bearing isocyanide, phosphine and N-heterocyclic carbene ancillary ligands have been prepared with high yields and selectivity. All the novel products underwent thorough characterization using spectroscopic techniques, including NMR and FT-IR analyses. Additionally, for some compounds, the solid-state structures were elucidated through X-ray diffractometry. The synthesized complexes were successively evaluated for their potential as anticancer agents against two ovarian cancer cell lines (A2780 and A2780cis) and one breast cancer cell line (MDA-MB-231). The majority of the compounds displayed promising cytotoxicity within the micromolar range against A2780 and MDA-MB-231 cells, with IC[sub.50] values comparable to or even surpassing those of cisplatin. However, only a subset of compounds was cytotoxic against cisplatin-resistant cancer cells (A2780cis). Furthermore, the assessment of antiproliferative activity on MRC-5 normal cells revealed certain compounds to exhibit in vitro selectivity. Notably, complexes 3d, 6a and 6b showed low cytotoxicity towards normal cells (IC[sub.50] > 100 µM) while concurrently displaying potent cytotoxicity against cancer cells.