Details

Autor(en) / Beteiligte

• Sanou, Abdoudramane
• Konaté, Kiessoun
• Belemnaba, Lazare
• Sama, Hemayoro
• Kaboré, Kabakdé
• Dakuyo, Roger
• Nitiéma, Mathieu
• Dicko, Mamoudou Hama

Titel

In Vivo Diuretic Activity and Anti-Hypertensive Potential of IHibiscus sabdariffa/I Extract by Inhibition of Angiotensin-Converting Enzyme and Hypertension Precursor Enzymes

Ist Teil von

• Foods, 2024-02, Vol.13 (4)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Aqueous extracts of calyx from Hibiscus sabdariffa (HS) (roselle) are highly appreciated for their nutritional and therapeutic effects, especially as anti-hypertensive substances. This study aimed to evaluate their anti-hypertensive potential through an in vitro inhibition assay of angiotensin-converting enzyme (ACE) and hypertension precursor enzymes and to assess the in vivo diuretic activity of HS. Results showed that HS extract inhibited enzymes belonging to several classes, such as α-amylase, trypsin, chymotrypsin, xanthine oxidase, lipoxygenase, and angiotensin-converting enzyme. In particular, enzymatic kinetics of ACE indicated a competitive inhibition fashion of HS extract. Furthermore, the extracts showed remarkable diuretic and natriuretic effects at doses of 50 mg/kg/bw, 100 mg/kg/b.w, and 200 mg/kg.b.w. These activities can be explained by the high content of phenolic compounds and essential amino acids. Roselle could be a potential source of nutraceuticals and anti-hypertensive bioactive compounds.