Details

Autor(en) / Beteiligte

• Ho, Hsin-Yu
• Lin, Chia-Chieh
• Lo, Yu-Sheng
• Chuang, Yi-Ching
• Abomughaid, Mosleh Mohammad
• Hsieh, Ming-Ju

Titel

Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from IPicrasma quassioides/I, Inhibits Metastasis of Head and Neck Squamous Cell Carcinoma

Ist Teil von

• International journal of molecular sciences, 2023-08, Vol.24 (17)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Head and neck squamous cell carcinoma (HNSCC) are associated with recurrence, distant metastasis, and poor overall survival. This highlights the need for identifying potential therapeutics with minimal side-effects. The present study was designed to investigate the anticancer effects of picrasidine J, a dimeric β-carboline-type alkaloid isolated from the southern Asian plant Picrasma quassioides. The results showed that picrasidine J significantly inhibits HNSCC cell motility, migration, and invasion. Specifically, picrasidine J inhibited the EMT process by upregulating E-cadherin and ZO-1 and downregulating beta-catenin and Snail. Moreover, picrasidine J reduced the expression of the serine protease KLK-10. At the signaling level, the compound reduced the phosphorylation of ERK. All these factors collectively facilitated the inhibition of HNSCC metastasis with picrasidine J. Taken together, the study identifies picrasidine J as a potential anticancer compound of plant origin that might be used clinically to prevent the distant metastasis and progression of HNSCC.