Details

Autor(en) / Beteiligte

• Cavalcante-Silva, Luiz Henrique Agra
• Almeida, Fernanda Silva
• Andrade, Arthur Gomes de
• Comberlang, Fernando Cézar
• Cardoso, Leonardo Lima
• Vanderley, Shayenne Eduarda Ramos
• Keesen, Tatjana S. L

Titel

IMycobacterium tuberculosis/I in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis

Ist Teil von

• International journal of molecular sciences, 2023-07, Vol.24 (14)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target.