Details

Autor(en) / Beteiligte

• Jin, Meiling
• Bang, Jin Seon
• Ha, Dae-Lyong
• Kim, Jun Young
• Park, Kyung Duck
• Lee, Weon Ju
• Lee, Seok-Jong
• Choi, Jin Kyeong
• Choi, Young-Ae
• Jang, Yong Hyun
• Kim, Sang-Hyun

Titel

IDermatophagoides farinae/I Extract Induces Interleukin 33-Mediated Atopic Skin Inflammation via Activation of RIP1

Ist Teil von

• International journal of molecular sciences, 2023-03, Vol.24 (6)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Receptor-interacting protein kinase (RIP) family 1 signaling has complex effects on inflammatory processes and cell death, but little is known concerning allergic skin diseases. We examined the role of RIP1 in Dermatophagoides farinae extract (DFE)-induced atopic dermatitis (AD)-like skin inflammation. RIP1 phosphorylation was increased in HKCs treated with DFE. Nectostatin-1, a selective and potent allosteric inhibitor of RIP1, inhibited AD-like skin inflammation and the expression of histamine, total IgE, DFE-specific IgE, IL-4, IL-5, and IL-13 in an AD-like mouse model. The expression of RIP1 was increased in ear skin tissue from a DFE-induced mouse model with AD-like skin lesions and in the lesional skin of AD patients with high house dust mite sensitization. The expression of IL-33 was down-regulated after RIP1 inhibition, and the levels of IL-33 were increased by over-expression of RIP1 in keratinocytes stimulated with DFE. Nectostatin-1 reduced IL-33 expression in vitro and in the DFE-induced mouse model. These results suggest that RIP1 can be one of the mediators that regulate IL-33-mediated atopic skin inflammation by house dust mites.