Details

Autor(en) / Beteiligte

• Nosel, Patrick
• Pflugrad, Henning
• Knitsch, Wolfgang
• Lanfermann, Heinrich
• Jackel, Elmar
• Barg-Hock, Hannelore
• Klempnauer, Jurgen
• Weissenborn, Karin
• Ding, Xiao-Qi

Titel

Brain Metabolic Alterations in Patients Shortly After Liver Transplantation

Ist Teil von

• Clinical neuroradiology (Munich), 2020-09, Vol.30 (S1), p.S16

Ort / Verlag

Springer

Erscheinungsjahr

2020

Quelle

SpringerLink

Beschreibungen/Notizen

• Background & Purpose: In the first few weeks after a liver transplantation (LTx) some patients present neurological abnormalities like impaired consciousness, confusion, hallucination and/or seizures, while their standard brain MR images did not show abnormal findings. Therefore a metabolic-toxically cause is currently assumed for the post-transplant encephalopathy (PTE), but the underlying pathomechanism is not yet clarified. Methods: 36 patients, 28 of them without PTE (Group P1) and 8 with PTE (Group P2) underwent shortly after LTx (within two weeks) phosphor 31 magnetic resonance spectroscopy examinations. The concentrations of metabolites Adenosintriphosphat (ATP), Phosphocreatin (PCr), Nicotinamidadenindinukleotid (NAD), Phosphodiester (PDE), Phosphomonoester (PME) and inorganic Phosphat (Pi) were determined. The results of the patient groups (P1 & P2) have been compared to those of a healthy control group (HC). Results: Our preliminary results showed that in comparison to the HC, both patients groups showed lowered ATP, increased PCr and PDE concentrations, but more distinct in patients with PTE, who revealed additionally decreased PME. Conclusion: Our first results showed alterations of brain metabolism in LTx patients. The special metabolic changes in P2 group indicated a possible participation of the cerebral metabolism in genesis of PTE.