Details

Autor(en) / Beteiligte

• Li, Yang
• Kong, Jichuan
• Zhao, Huan
• Liu, Yao

Titel

Synthesis of Multi-Stimuli Responsive Fe[sub.3]O[sub.4] Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy

Ist Teil von

• Molecules (Basel, Switzerland), 2023-02, Vol.28 (4)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Nanodiamonds with magnetic resonance imaging (MRI) and targeted drug delivery to exert combined effects for biomedical applications have been considered to be an urgent challenge. Herein, a novel bio-nanoarchitectonics (Fe[sub.3]O[sub.4]@NDs) with simultaneous imaging and therapeutic capacities was fabricated by covalently conjugating nanodiamonds (NDs) with Fe[sub.3]O[sub.4]. Fe[sub.3]O[sub.4]@NDs exhibited better biocompatibility and excellent photothermal stability with superb photothermal conversion performance (37.2%). Fe[sub.3]O[sub.4]@NDs has high doxorubicin (DOX) loading capacity (193 mg/g) with pH and NIR-responsive release characteristics. Fe[sub.3]O[sub.4]@NDs loading DOX showed a combined chemo-photothermal inhibitory effect on the tumor cells. Enhanced T[sub.2]-weighted MRI contrast toward the tumor, with the assistance of a magnetic field, convinced the Fe[sub.3]O[sub.4]@NDs gathered in the tumor more efficiently and could be used for MRI-based cancer diagnosis. Our results revealed an effective strategy to achieve a stimuli-sensitive nanoplatform for multifunctional theranostics by the combined action.