Details

Autor(en) / Beteiligte

• Dawar, R
• Yadav, A
• Jain, A
• Ramteke, A
• Tripathi, B.K
• Mamta
• Suganha
• Sunita
• Dhananjay

Titel

Serum Folate and Vitamin B12 Levels in Acute MI Patients-a Case Control Study: Indian Population

Ist Teil von

• Indian journal of clinical biochemistry, 2022-05, Vol.34 (S1), p.S202

Ort / Verlag

Springer

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The incidence of coronary artery disease (CAD) is increasing at an alarming rate, especially in developing countries, such as India. It is often advocated that a vegetarian lifestyle could reduce the burden of CAD. However, in spite of a majority of Indians being vegetarians, the incidence of CAD is still very high in this population. In this study we estimated levels of vitamin B12 and Folate in patients of acute MI and compared them with controls. Individuals presenting to medicine emergency with clinical features suggestive of myocardial infarction, after detailed clinical examination, were screened with help of electrocardiographic and biochemical markers (increase in cardiac enzymes). 52 patients with evidence of fresh myocardial infarction, after satisfying the inclusion and exclusion criteria, were taken up for the study. 73 controls with no past or present history of myocardial infarction were also included in the study. Their serum samples (cases and controls) were analyzed for levels of Folate and vitamin B12 by ELISA, serum Folate levels in Cases (6.45 ng/ml) was significantly lower as compared to controls (14.78 ng/ml) with p value <0.001. Also, vitamin B12 levels were (0.54 ng/ml) was significantly lower in cases compared to controls (2.42 ng/ml) with p value <0. 001. So, we conclude that reduced levels of Folate and vitamin B12 can be considered as high risk factors for occurrence of Ml, by virtue of their direct and indirect effects. However, more studies with larger samples are needed to confirm risk associated with reduced levels of these vitamins with MI.