Details

Autor(en) / Beteiligte

• Malik, Isha
• Dalal, Deepika
• Arya, Amit

Titel

Evaluation of Serum Electrolyte Pattern and LDH in Hypothyroidism and their Correlation

Ist Teil von

• Indian journal of clinical biochemistry, 2022-05, Vol.34 (S1), p.S133

Ort / Verlag

Springer

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Thyroid hormone is a central regulator of body hemodynamics, thermoregulation and metabolic functions and in the disorders of thyroid gland signs are often nonspecific. Both subclinical hypothyroidism and hyperthyroidism are associated with an increased risk of disease, as well as alteration in biochemical and physiologic measures in patients with overt thyroid disease. In severe hypothyroidism and myxedema hyponatremia was described to be a consequence of enhanced renal water retention mediated by vasopressin. Lactate dehydrogenase (LDH) is an enzyme found in nearly all living cells. It catalyzes the conversion of lactate to pyruvate and back, as it converts [NAD.sup.+] to NADH. However, only a few studies have investigated serum lactate dehydrogenase activity in patients with thyroid dysfunction. To estimate the levels of serum electrolytes like sodium, potassium and magnesium along with LDH in hypothyroid patients and to correlate them. The study population was serum specimens from 50 patients with hypothyroidism (as per the reports available) with age ranging from 25-65 years. The samples were collected from the Thyroid laboratory, Department of Biochemistry, PGIMS, Rohtak. The serum electrolytes like sodium and potassium were estimated by the electrolyte analyzer whereas the concentrations of magnesium and LDH were determined on the autoanalyzer. The mean values for Na, K, Mg, and LDH were found to be 132.82 [+ or -] 22.10, 6.06 [+ or -] 2.85, 2.2 [+ or -] 0.5 and 910 [+ or -] 1771. There was statistically insignificant positive correlation between Na and Mg, K and Mg, Mg and LDH while there was statistically insignificant negative correlation between Na and LDH, K and LDH. Our findings support the fact that hypothyroid patients are having subtle disturbances of electrolytes and LDH levels.