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Antihyperglyceamic Potential of Aqueous Extract of Different Parts of Butea Monosperma on Alloxan Induced Diabetic Rats: A Comparative Study
Ist Teil von
Indian journal of clinical biochemistry, 2022-05, Vol.32 (S1), p.S226
Ort / Verlag
Springer
Erscheinungsjahr
2022
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
The anti-hyperglyceamic and anti-oxidant potential of the aqueous extract of various parts of B. monosperma was evaluated in alloxan (ALXN)-induced diabetic male adult rats. Experimental animals were divided into eight groups viz., I, II, III, IV, V, VI, VII, and VIII. Diabetes mellitus (DM) was induced in groups II--VIII rats by a single intraperitoneal injection of alloxan (150 mg/kg body wt). Group I (control mice) received an equal volume of normal saline. Group IIIVIII were further treated with BMF, BMS, BML, BMB and BMR (500 mg/kg body wt, p.o.) representing, flower, seed, leave, stem bark and root of BM respectively for a period of 21 days. Body weight, food and water intake and fasting blood glucose (FBG) levels were measured at periodic intervals during the test period. At the end of treatment period, blood was collected by cardiac puncture under mild ether anesthesia and serum was isolated to analyze serum insulin levels. The homogenates of pancreatic was also analyzed for both enzymatic and nonenzymatic antioxidants, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and total protein (TP). Alloxan injection resulted in a significantly (P < 0.05) increased concentration of FBG level. The FBG level decreased significantly (P < 0.05) after 21 days treatment of BM parts.