Details

Autor(en) / Beteiligte

• Ivankin, D. I.
• Borisova, M. S.
• Sokolov, D. N.
• Luzina, O. A.
• Tolstikova, T. G.
• Salakhutdinov, N. F.

Titel

Design, Synthesis, and Anti-Ulcer Activity of New 1-Thia-4,8-Diazaspiro[4,5]Decan-3-One Derivatives

Ist Teil von

• Pharmaceutical chemistry journal, 2022-03, Vol.55 (12), p.1288-1292

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Aseries of compounds based on 1-thia-4,8-diazaspiro[4.5]decan-3-one was synthesized. Their activity as new anti-ulcer agents was investigated in vivo . 8-Benzyl-4-[3-(dimethylamino)propyl]-1-thia-4,8-diazaspiro-[4,5]decan-3-one, 8-benzyl-4-[2-(dimethylamino)ethyl]-1-thia-4,8-diazaspiro[4,5]decan-3-one, 4,8-dibenzyl-1-thia-4,8-diazaspiro[4,5]decan-3-one, and 8-benzyl-4-[3-(dibutylamino)propyl]-1-thia-4,8-diazaspiro[4,5]-decan-3-one were found to possess anti-ulcer activity comparable with that of omeprazole.