Details

Autor(en) / Beteiligte

• Radwan, Eman M.
• Elsayed, Elsherbiny H.
• El-Moneim, Mohamed Abd
• Youssef Moustafa, Amal M.

Titel

Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives

Ist Teil von

• Pharmaceutical chemistry journal, 2022, Vol.55 (10), p.1040-1049

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and condensation of ethyl 7-hydroxycoumarin-3-carboxylate with 4,6-dibromo-3-amino phenol. Acylation with acetic anhydride and condensation of coumarin derivatives with 2-hydroxybenzaldehyde yielded the corresponding acetyl derivatives and 4-substituted pyrazole derivatives. Structures of the synthesized compounds were elucidated by spectral methods and elemental analysis. All the prepared derivatives were evaluated for their cytotoxicity against human breast carcinoma cell line (MCF-7). Compound VI showed the least IC 50 value in MTT colorimetric assay as compared to that of the standard marketed drug staurosporin.