Details

Autor(en) / Beteiligte

• Thompson, Elizabeth W
• Kamesh Iyer, Srikant
• Solomon, Michael P
• Li, Zhaohuan
• Zhang, Qiang
• Piechnik, Stefan
• Werys, Konrad
• Swago, Sophia
• Moon, Brianna F
• Rodgers, Zachary B
• Hall, Anya
• Kumar, Rishabh
• Reza, Nosheen
• Kim, Jessica
• Jamil, Alisha
• Desjardins, Benoit
• Litt, Harold
• Owens, Anjali
• Witschey, Walter R. T
• Han, Yuchi

Titel

Endogenous T1[rho] cardiovascular magnetic resonance in hypertrophic cardiomyopathy

Ist Teil von

• Journal of cardiovascular magnetic resonance, 2021-10, Vol.23 (1)

Ort / Verlag

BioMed Central Ltd

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background Hypertrophic cardiomyopathy (HCM) is characterized by increased left ventricular wall thickness, cardiomyocyte hypertrophy, and fibrosis. Adverse cardiac risk characterization has been performed using late gadolinium enhancement (LGE), native T1, and extracellular volume (ECV). Relaxation time constants are affected by background field inhomogeneity. T1[rho] utilizes a spin-lock pulse to decrease the effect of unwanted relaxation. The objective of this study was to study T1[rho] as compared to T1, ECV, and LGE in HCM patients. Methods HCM patients were recruited as part of the Novel Markers of Prognosis in Hypertrophic Cardiomyopathy study, and healthy controls were matched for comparison. In addition to cardiac functional imaging, subjects underwent T1 and T1[rho] cardiovascular magnetic resonance imaging at short-axis positions at 1.5T. Subjects received gadolinium and underwent LGE imaging 15-20 min after injection covering the entire heart. Corresponding basal and mid short axis LGE slices were selected for comparison with T1 and T1[rho]. Full-width half-maximum thresholding was used to determine the percent enhancement area in each LGE-positive slice by LGE, T1, and T1[rho]. Two clinicians independently reviewed LGE images for presence or absence of enhancement. If in agreement, the image was labeled positive (LGE + +) or negative (LGE --); otherwise, the image was labeled equivocal (LGE + -). Results In 40 HCM patients and 10 controls, T1 percent enhancement area (Spearman's rho = 0.61, p < 1e-5) and T1[rho] percent enhancement area (Spearman's rho = 0.48, p < 0.001e-3) correlated with LGE percent enhancement area. T1 and T1[rho] percent enhancement areas were also correlated (Spearman's rho = 0.28, p = 0.047). For both T1 and T1[rho], HCM patients demonstrated significantly longer relaxation times compared to controls in each LGE category (p < 0.001 for all). HCM patients also showed significantly higher ECV compared to controls in each LGE category (p < 0.01 for all), and LGE -- slices had lower ECV than LGE + + (p = 0.01). Conclusions Hyperenhancement areas as measured by T1[rho] and LGE are moderately correlated. T1, T1[rho], and ECV were elevated in HCM patients compared to controls, irrespective of the presence of LGE. These findings warrant additional studies to investigate the prognostic utility of T1[rho] imaging in the evaluation of HCM patients. Keywords: Hypertrophic cardiomyopathy, T1[rho], LGE, T1