Details

Autor(en) / Beteiligte

• Mitrakova, D. O.
• Chernikov, M. V.
• Spasov, A. A.
• Morkovnik, A. S.
• Remezova, I. P.
• Bunyatyan, N. D.
• Morosov, A. V.
• Divaeva, L. N.
• Zhukovskaya, O. N.

Titel

Synthesis, Analysis, and Acute Toxicity of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-α]benzimidazole Dinitrate

Ist Teil von

• Pharmaceutical chemistry journal, 2021-09, Vol.55 (6), p.544-550

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2021

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• The key synthetic stage (cyclization) of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-α]benzimidazole dinitrate, which possesses antiulcer activity, was improved by changing the reaction medium and using the imine itself rather than its hydrobromide for the cyclization. A method using the physicochemical properties (NMR and IR spectroscopy and UV spectrophotometry) of the substance was proposed for identifying it. An HPLC method was proposed for determining related impurities; nonaqueous titration, for quantitative determination. Acute toxicity was studied in mice and rats upon intragastric and intravenous administration. The results showed that the drug substance had class 3 moderate toxicity upon both intragastric and intravenous administration.