Details

Autor(en) / Beteiligte

• Urooj Nazim, Urooj Nazim
• Silpa Narayanan, Silpa Narayanan
• Mohsin Ali, Mohsin Ali
• Khalid Mohammed Khan, Khalid Mohammed Khan
• Basharat Ali, Basharat Ali
• Jonathan Li, Jonathan Li
• Zhe Sheng Chen, Zhe Sheng Chen
• Mansoor Ahmed and Dong Hua Yang, Mansoor Ahmed and Dong Hua Yang

Titel

Synthesis, Characterization and Cytotoxic Effect of Some New Thiazolyl Hydrazone Derivatives of 1-Indanone

Ist Teil von

• Journal of the Chemical Society of Pakistan, 2021-04, Vol.43 (2), p.244-244

Ort / Verlag

Knowledge Bylanes

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25and#177;0.02 to 5.04and#177;0.2 and#181;M. On the other hand all the compounds didn’t show cytotoxic activity against other forms of human cancer cells.