Details

Autor(en) / Beteiligte

• Erbay, Mehmet Fatih
• Kartalci, Sukru

Titel

Insular volume reduction in young male schizophrenia patients/Genc erkek sizofreni hastalarinda insular hacim azalmasi

Ist Teil von

• Anadolu psikiyatri dergisi, 2020-12, Vol.21 (6), p.579

Ort / Verlag

Anadolu Psikiyatri Dergisi

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective: Recent developments in neuroimaging have advanced the understanding of biological mechanisms underlying schizophrenia. Structural and functional abnormalities of the insular cortex have been reported in schizophrenia patients. Many studies have demonstrated that insula volume is lower in schizophrenia patients than healthy individuals. The present study aimed to compare insula volumes of young male schizophrenia patients with that of age-matched young healthy male subjects to eliminate age and gender bias. Methods: Twenty-three male schizophrenia patients meeting DSM5 diagnostic criteria, who were at the age of 18-40 years, and age-matched 25 healthy male subjects were included into the study. All patients magnetic resonance imaging (MRI) procedure was completed. Insula volume of schizophrenia patients and healthy male volunteers was calculated using MRICloud method. Disease severity was assessed using Positive and Negative Symptom Scale (PANSS). Results: Volumes of both the left and the right insula were significantly lower in the patient group vs. the control group. Moreover, a positive correlation was determined between the right insula volume and the scores of positive symptom severity scale. Conclusion: Decreased insular volume is not a specific marker, but it may be a general marker regarding psychopathology. However, investigating whether the diagnostic specificity of insular cortex abnormalities in psychopathologies will be the focus of future studies. (Anatolian Journal of Psychiatry 2020; 21(6):579-584) Key words: schizophrenia, insular cortex, MRICloud, neuroimaging Amac: Norogoruntuleme alanindaki son gelismeler sizofreninin altinda yatan biyolojik mekanizmalarin anlasilmasini artirmistir. Sizofreni hastalarinda insular korteksin yapisal ve islevsel anormallikleri bildirilmistir. Cogu calisma sizofreni hastalarindaki insular hacimlerin saglikli insanlardan daha az oldugunu gostermistir. Bu calismada yas ve cinsiyet gibi degiskenlerin kontrol altina alinmasi amaci ile genc, erkek sizofreni hastalarinda ve yas olarak eslestirilmis saglikli genc erkek gonullulerde insula hacimlerinin karsilastirilmasi amaclanmistir. Yontem: Sizofreni icin DSM-5 tani olcutlerini karsilayan 18-45 yaslari arasindaki 23 erkek sizofreni hastasi ve ayni yas grubunda 25 saglikli gonullu erkek calismaya alindi. Tum hastalarda manyetik rezonans goruntuleme (MRG) islemi tamamlandi. Sizofreni hastalarinin ve saglikli erkek gonullulerin insula hacmi MRICloud yontemi kullanilarak hesaplandi. Hastalik siddeti Pozitif ve Negatif Semptom Skalasi (PANSS) ile belirlendi. Bulgular: Hem sag, hem de sol insula hacmi hasta grubunda kontrol grubuna gore anlamli duzeyde daha kucuktu. Ayrica sag insula hacmi ile pozitif semptom siddeti olcek puanlari arasinda pozitif korelasyon saptandi. Tartisma: Azalan insular hacim ozgul bir hastalik belirteci degildir, ancak psikopatolojiye iliskin genel bir belirtec olabilir. Bununla birlikte psikopatolojilerde insular korteks anormalliklerinin tanisal ozgullugunun olup olmadiginin arastirilmasi gelecekteki calismalarin odak noktasi olacaktir. (Anadolu Psikiyatri Derg 2020; 21(6):579-584) Anahtar sozcukler: Sizofreni, insular korteks, MRICloud, norogoruntuleme