Details

Autor(en) / Beteiligte

• Braun, L. A.
• Varpetyan, E. E.
• Zav’yalov, G. A.
• Kulikov, F. V.
• Marievskii, V. E.
• Tyul’ganova, D. A.
• Shishnenko, A. O.
• Stepanova, D. S.
• Shimanovskii, N. L.

Titel

Metabolic Enzymes: New Targets for the Design of Antitumor Drugs

Ist Teil von

• Pharmaceutical chemistry journal, 2020-09, Vol.54 (6), p.547-554

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The awareness of malignant metabolism transformations has recently emerged. Since Otto Warburg found that tumor cells prefer glycolysis to oxidative phosphorylation even in the presence of oxygen, studies have shown that cancer cells also depend on upregulated fatty-acid synthesis and glutaminolysis. The present review covers the key metabolic enzymes known as metabolic oncogenes and suggests ways of modulating their activity. It is concluded that metabolic transformations during carcinogenesis present opportunities for targeted action on neoplasms and provide a new field for antitumor drug development.