Details

Autor(en) / Beteiligte

• Gerayeli, Farhad Ghanizadeh
• Hosseini, Farnaz
• Bagheri, Zohreh
• Savardashtaki, Amir
• Shabaninejad, Zahra
• Amani, Ali Mohammad
• Najafipour, Sohrab

Titel

Colorimetric Sensor Based on [beta]-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination

Ist Teil von

• International journal of analytical chemistry, 2020-06, Vol.2020

Ort / Verlag

John Wiley & Sons, Inc

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. It is a reverse transcriptase inhibitor. This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients' blood. Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs. In this study, we synthesized AgNP-modified [beta]- cyclodextrin ([beta]-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination. Characterization of nanoparticles was done using different methods including infrared (IR) spectroscopy, ultraviolet- visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and also, X-ray diffraction (XRD) patterns. The AgNP [lambda]-max peak was at approximately 405 nm. In the presence of ZDV, yellow solution was turned to red color, and surface plasmon absorption band was dramatically centered at 560 nm. ZDV was determined in the range of 50-500 [micro]M, and the detection limit value was obtained as 42 [micro]M. The sensor was used to determine ZDV in tablets with good recovery.