Details

Autor(en) / Beteiligte

• Kulikova, T.G
• Stepanova, O.V
• Voronova, A.D
• Valikhov, M.P
• Kuznetsova, T.V
• Kurilina, E.V
• Akchurin, R.S
• Reshetov, I.V
• Sukhikh, G.T

Titel

Energy Metabolism in Cellular Regenerative Processes: Focus on PPAR[alpha]

Ist Teil von

• Bulletin of experimental biology and medicine, 2020-03, Vol.168 (5), p.658

Ort / Verlag

Springer

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Reduced expression of the key regulator of cardiac metabolism, transcription factor PPAR[alpha], in surgical samples of the auricles from patients with coronary heart disease and heart failure was detected by real-time quantitative PCR. These changes indicate reduced activity of this factor and a shift of energy metabolism from oxidative phosphorylation to glycolysis typical of dedifferentiated cells. Electron microscopy revealed dedifferentiated cardiomyocytes with disassembled contractile apparatus and disorganized sarcomeres. In the examined specimens from patients with heart failure, severe myocardial fibrosis was revealed. Key Words: cellular regenerative processes; energy metabolism; PPAR[alpha]; fetal genetic program; cell dedifferentiation