Details

Autor(en) / Beteiligte

• El-Bidawy, Mahmoud H
• Bastawy, Nermeen
• Khalifa, Mohamed Mansour
• Abdulla, Hanan
• Elsayed, Rania
• Rashed, Laila
• Niazy, Marwa
• Al-Ghamdi, Sameer
• Haidara, Mohamed A

Titel

High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats/Dieta Rica en Grasas Aumenta la Resorcion Osea Inducida por Ovariectomia en Ratas

Ist Teil von

• International journal of morphology, 2020-03, Vol.38 (1), p.129

Ort / Verlag

Universidad de La Frontera, Facultad de Medicina

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-[alpha]) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats. KEY WORDS: Ovariectomy; Menopause; Inflammation; NF-kB, Dyslipidemia; Rat model.