Details

Autor(en) / Beteiligte

• Liek, Elisabeth
• Wunderlich, Heiko
• Elsebach, Klaus
• Gobel, Hubert
• Krah, Xaver
• Krautschick-Wilkens, Andreas W
• Schweiger, Josef
• Steiner, Gabriel
• Steiner, Thomas
• Heinzelmann, Joana

Titel

The Overall Survival Benefit for Patients with T1 Renal Cell Carcinoma after Nephron-Sparing Surgery Depends on Gender and Age: A Retrospective Multi-Centre Study Comparing the Overall Survival Benefit of Patients with T1 Renal Cell Carcinoma Undergoing Either Radical Nephrectomy or Partial Nephrectomy in Order to the Age and the Gender of the Patients

Ist Teil von

• Urologia internationalis, 2018-04, Vol.100 (3)

Ort / Verlag

S. Karger AG

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Due to the recommendations in the urological guidelines to perform nephron-sparing surgery in patients with organ-confined renal cell carcinoma (RCC), the customary therapy regimen changed, but it is not well studied yet whether partial nephrectomy (PN) especially in the elderly is beneficial. From 2000 to 2015, 3,592 patients from 7 clinics undergoing surgery in RCC were identified; 2,323 had T1 tumours. We retrospectively compared the overall survival benefit of patients with T1 RCC who underwent either PN or radical nephrectomy (RN) and studied effects of age and gender. Results: In T1 RCC, PN was beneficial in male patients (p = 0.0006) independent of age, especially in those men [less than or equal to]75 years of age (p = 0.0005); but PN was not beneficial for female patients (p = 0.0629) regardless of age and male patients older than 75 years (p = 0.736). The OS of female patients after RN and male patients after PN is the same, regardless of age. A life expectancy of more than 45 months at least is necessary to experience an overall survival benefit after PN. Conclusions: There should be harder proven indications for PN in female patients and especially in all patients older than 75 years, particularly with regard to perioperative risk factors. Keywords Renal cell carcinoma * Nephrectomy * Partial nephrectomy * Age * Gender * Overall survival