Details

Autor(en) / Beteiligte

• Yu, Binbin
• Zhu, Xiaodong
• Liang, Zhongguo
• Sun, Yongchu
• Zhao, Wei
• Chen, Kaihua

Titel

Clinical usefulness of [.sup.18]F-FDG PET/CT for the detection of distant metastases in patients with non-small cell lung cancer at initial staging: a meta-analysis

Ist Teil von

• Cancer management and research, 2018-01, Vol.10, p.1859

Ort / Verlag

Dove Medical Press Limited

Erscheinungsjahr

2018

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Background: We undertook a meta-analysis to evaluate the clinical usefulness of [.sup.18]F-fluorodeoxyglucose positron emission tomography/computed tomography ([.sup.18]F-FDG PET/CT) for the detection of distant metastases in patients with non-small cell lung cancer (NSCLC) at initial staging. Materials and methods: All topic-related studies were comprehensively searched in the MEDLINE and Embase databases. We obtained the summary estimates and constructed the summary receiver operating characteristic curve for [.sup.18]F-FDG PET/CT using the bivariate regression model. Results: Across 10 studies (1333 patients), the sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for [.sup.18]F-FDG PET/CT were 0.81 (95% confidence interval [CI] = 0.63-0.92), 0.96 (95% CI = 0.94-0.98), 22.9 (95% CI = 13.3-39.5), and 0.20 (95% CI = 0.09-0.42), respectively. Overall weighted area under the curve was 0.97 (95% CI = 0.96-0.98). Conclusion: [.sup.18]F-FDG PET/CT has a good diagnostic performance for distant metastasis staging in patients with NSCLC at initial staging. Keywords: [.sup.18]F-FDG PET/CT, distant metastasis, lung cancer, meta-analysis