Details

Autor(en) / Beteiligte

• Alemany, Silvia
• Vilor-Tejedor, Natalia
• Garcia-Esteban, Raquel
• Bustamante, Mariona
• Dadvand, Payam
• Esnaola, Mikel
• Mortamais, Marion
• Forns, Joan
• van Drooge, Barend L
• Alvarez-Pedrerol, Mar
• Grimalt, Joan O
• Rivas, Ioar
• Querol, Xavier
• Pujol, Jesus
• Sunyer, Jordi

Titel

Traffic-Related Air Pollution, APOE [epsilon]4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project

Ist Teil von

• Environmental health perspectives, 2018-08, Vol.126 (8)

Ort / Verlag

National Institute of Environmental Health Sciences

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background: Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the [epsilon]4 allele of Apolipoprotein E (APOE) gene, the primary genetic risk factor for AD. Objective: We analyzed whether the association between traffic air pollution and neurodevelopmental outcomes is modified by APOE [epsilon]4 status in children. Methods: Data on parent-reported behavior problems (total difficulties scores, Strengths and Difficulties Questionnaire), teacher-reported attention-deficit hyperactivity disorder (ADHD) symptom scores, cognitive performance trajectories (computerized tests of inattentiveness and working memory repeated 2-4 times during January 2012-March 2013), and APOE genotypes were obtained for 1,667 children age 7-11 y attending 39 schools in or near Barcelona. Basal ganglia volume (putamen, caudate, and globus pallidum) was measured in 163 of the children by MRI (October 2012-April 2014.) Average annual outdoor polycyclic aromatic hydrocarbons (PAHs), elemental carbon (EC), and nitrogen dioxide (N[O.sub.2]) concentrations were estimated based on measurements at each school (two 1-wk campaigns conducted 6 months apart in 2012). Results: APOE [epsilon]4 allele carriers had significantly higher behavior problem scores than noncarriers, and adverse associations with PAHs and N[O.sub.2] were stronger or limited to [epsilon]4 carriers for behavior problem scores (P-interaction 0.03 and 0.04), caudate volume (P-interaction 0.04 and 0.03), and inattentiveness trajectories (P-interaction 0.15 and 0.08, respectively). Patterns of associations with the same outcomes were similar for EC. Conclusion: PAHs, EC, and N[O.sub.2] were associated with higher behavior problem scores, smaller reductions in inattentiveness over time, and smaller caudate volume in APOE [epsilon]4 allele carriers in our study population, and corresponding associations were weak or absent among [epsilon]4 noncarriers. These findings support a potential role of APOE in biological mechanisms that may contribute to associations between air pollution and neurobehavioral outcomes in children.