Details

Autor(en) / Beteiligte

• Gloria-Bottini, Fulvia
• Pietropolli, Adalgisa
• Neri, Anna
• Coppeta, Luca
• Magrini, Andrea
• Bottini, Egidio

Titel

A study of adenylate kinase locus 1 ([Ak.sub.1]) genetic polymorphism in diabetic pregnancy

Ist Teil von

• Faṣlnāmah-i pizishkī-i bārvar va nābārvar, 2014-07, Vol.15 (3), p.161

Ort / Verlag

Avicenna Research Institute

Erscheinungsjahr

2014

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background: Previous studies suggest that adenylate kinase locus 1 ([Ak.sub.1]) has an important role in the control of blood glucose level and in the glycation of structural and functional proteins in type 2 diabetes and in the balanced development of feto-placental unit in healthy puerperae (HP). In this study, an attempt was made to investigate the relationship of [Ak.sub.1] with maternal and neonatal parameters in puerperae with gestational diabetes (GDP) and with preexisting type 1 diabetes (T1DP). Methods: This study was carried on 402 HP, 347 consecutive healthy newborns, 102 GDP and 111 T1DP with their newborn infants. [Ak.sub.1] phenotype was determined by starch gel electrophoresis. Chi-square test of independence was carried out by SPSS program. The analysis of three way contingency table was carried out by a loglinear model. Significant level was 0.05. Results: In T1DP, the frequency of [Ak.sub.1.sup.*]2 allele was higher than in GDP and in HP. Serum glucose level was higher in T1DP than in GDP with higher values in carriers of [Ak.sub.1.sup.*]2 allele. Neonatal hypoglycemia was more frequent in T1DP than in GDP with a positive association with [Ak.sub.1.sup.*]2 allele. The correlation between birth weight (BW) and placental weight (PW) was lower in infants from T1DP than HP. In healthy puerperae the correlation is higher in [Ak.sub.1] 2-1 than in [Ak.sub.1]1 phenotype while in diabetic puerperae the pattern is reversed with lower values in [Ak.sub.1]2-1 than in [Ak.sub.1]1 phenotype. The lowest value of correlation is observed in infants from T1D mothers carrying the [Ak.sub.1.sup.*]2 allele. Conclusion: The data confirmed the involvement of [Ak.sub.1] in glucose metabolism and showed a disturbance of the balance between placental and fetal growth which was more marked in T1DP. Keywords: Adenylate kinase, BW-PW correlation, Gestational diabetes, Neonatal hypoglycemia, Preexisting T1D.