Phytomedicine (Stuttgart), 2014-07, Vol.21 (8-9), p.1070-1077
2014
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- Autor(en) / Beteiligte
- Titel
- Propolis cinnamic acid derivatives induce apoptosis through both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA expression
- Ist Teil von
- Phytomedicine (Stuttgart), 2014-07, Vol.21 (8-9), p.1070-1077
- Ort / Verlag
- Germany: Elsevier GmbH
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Propolis cinnamic acid derivatives have a number of biological activities including anti-oxidant and anti-cancer ones. In this study, we aimed to elucidate the mechanism of the anti-cancer activity of 3 representative propolis cinnamic acid derivatives, i.e., Artepilin C, Baccharin and Drupanin in human colon cancer cell lines. Our study demonstrated that these compounds had a potent apoptosis-inductive effect even on drug-resistant colon cancer cells. Combination treatment of human colon cancer DLD-1 cells with 2 of these compounds, each at its IC20 concentration, induced apoptosis by stimulating both intrinsic and extrinsic apoptosis signaling pathways. Especially, Baccharin plus Drupanin exhibited a synergistic growth-inhibitory effect by strengthening both intrinsic and extrinsic apoptotic signaling transduction through TRAIL/DR4/5 and/or FasL/Fas death-signaling loops and by increasing the expression level of miR-143, resulting in decreased expression levels of the target gene MAPK/Erk5 and its downstream target c-Myc. These data suggest that the supplemental intake of these compounds found in propolis has enormous significance with respect to cancer prevention.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0944-7113eISSN: 1618-095XDOI: 10.1016/j.phymed.2014.04.006Titel-ID: cdi_gale_infotracmisc_A375290550
- Format
- –
- Schlagworte
- Antineoplastic Agents, Phytogenic - chemistry, Antineoplastic Agents, Phytogenic - isolation & purification, Antineoplastic Agents, Phytogenic - pharmacology, Apoptosis, Apoptosis - drug effects, Cancer, Carboxylic acids, Caspase Inhibitors - pharmacology, Cell Line, Tumor, Cell Survival - drug effects, Cinnamates - chemistry, Cinnamates - isolation & purification, Cinnamates - pharmacology, Colonic Neoplasms - drug therapy, Drug Synergism, Fas Ligand Protein - genetics, Female, Fluorouracil - pharmacology, Gene Expression Regulation, Neoplastic, Humans, Medicine, Traditional, MicroRNAs - genetics, miR-143, Models, Biological, Oncology, Experimental, Organoplatinum Compounds - pharmacology, Oxaliplatin, Phenylpropionates - chemistry, Phenylpropionates - isolation & purification, Phenylpropionates - pharmacology, Phytochemicals, Prevention, Properties, Propolis, Propolis - analogs & derivatives, Propolis - chemistry, Propolis - isolation & purification, Propolis - pharmacology, Propolis cinnamic acid derivatives, Signal Transduction - drug effects, TNF family, TNF-Related Apoptosis-Inducing Ligand - genetics, Trichothecenes - chemistry, Trichothecenes - isolation & purification, Trichothecenes - pharmacology, Up-Regulation