Details

Autor(en) / Beteiligte

• Alessi, P
• Cortesi, A
• De Zordi, N
• Gamse, T
• Kikic, I
• Moneghini, M
• Solinas, D

Titel

Supercritical antisolvent precipitation of quercetin systems: preliminary experiments

Ist Teil von

• Chemical and biochemical engineering quarterly, 2012-10, Vol.26 (4), p.391

Ort / Verlag

Croatian Association of Chemical Engineers

Erscheinungsjahr

2012

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Flavonoids have attracted a lot of attention due to their antioxidant, antitumor and antibacterial activities. Quercetin (3,5,7,3,4-pentahydroxyflavone) is a polyphenolic flavonoid that shows several biological effects including a strong inhibitory effect on the growth of several human and animal cancer cell lines and enhances the antiproliferative effect of cisplatin both in-vitro and in-vivo. In spite of a variety of its biological effects, Quercetin is very poorly soluble in water, which has limited its absorption upon oral administration. As known, the solubility of drug is often due to the increase of the surface/volume ratio which implies the increase of the number of surface atoms (or molecules) with respect to the number of bulk atoms (or molecules). With this aim, we investigated the use of supercritical antisolvent (SAS) technique for Quercetin microparticles generation finding the best operative conditions through the Peng Robinson's Equation of State. The obtained simulation behaviors were confirmed by experimental precipitation: the physicochemical characterizations of the samples were also performed. Key words: Quercetin, supercritical antisolvent technique, micronisation, physicochemical characterization