Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Taste-independent nutrient selection is mediated by a brain-specific [Na.sup.+]/solute co-transporter in Drosophila
Ist Teil von
Nature neuroscience, 2013-05, Vol.16 (5), p.526
Ort / Verlag
Nature Publishing Group
Erscheinungsjahr
2013
Quelle
EBSCO_Psychology & Behavioral Sciences Collection
Beschreibungen/Notizen
Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.