Details

Autor(en) / Beteiligte

• DE BERARDIS, Giorgia
• PELLEGRINI, Fabio
• VALENTINI, Miriam
• NICOLUCCI, Antonio
• FRANCIOSI, Monica
• BELFIGLIO, Maurizio
• DI NARDO, Barbara
• GREENFIELD, Sheldon
• KAPLAN, Sherrie H
• ROSSI, Maria C. E
• SACCO, Michele
• TOGNONI, Gianni

Titel

Longitudinal Assessment of Quality of Life in Patients With Type 2 Diabetes and Self-Reported Erectile Dysfunction

Ist Teil von

• Diabetes care, 2005-11, Vol.28 (11), p.2637-2643

Ort / Verlag

Alexandria, VA: American Diabetes Association

Erscheinungsjahr

2005

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Longitudinal Assessment of Quality of Life in Patients With Type 2 Diabetes and Self-Reported Erectile Dysfunction Giorgia De Berardis , MSCPHARMCHEM , Fabio Pellegrini , MSCSTAT , Monica Franciosi , MSCBIOLS , Maurizio Belfiglio , MD , Barbara Di Nardo , HSDIP , Sheldon Greenfield , MD , Sherrie H. Kaplan , PHD, MPH , Maria C.E. Rossi , MSCPHARMCHEM , Michele Sacco , MD , Gianni Tognoni , MD , Miriam Valentini , MD , Antonio Nicolucci , MD and on behalf of the QuED (Quality of Care and Outcomes in Type 2 Diabetes) Study Group * Address correspondence and reprint requests to Antonio Nicolucci, MD, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 S. Maria Imbaro (CH), Italy. E-mail: nicolucci{at}negrisud.it Abstract OBJECTIVE —In the context of the QuED (Quality of Care and Outcomes in Type 2 Diabetes) project, we evaluated the longitudinal changes over 3 years in quality of life (QoL) in patients with type 2 diabetes according to the presence or the development of erectile dysfunction (ED). RESEARCH DESIGN AND METHODS —Patients were requested to fill in a questionnaire investigating the presence of ED and QoL (SF-36 Health Survey, depression symptoms [Center for Epidemiologic Studies–Depression], and quality of sexual life) every 6 months for 3 years. The analyses were based on multilevel models, adjusted for patient clinical and sociodemographic characteristics. RESULTS —The study involved 1,456 patients, of whom 34% reported frequent erectile problems at baseline; 192 developed ED during the follow-up. No changes in QoL measures were detected in patients without ED; in those with ED at baseline, a worsening in all SF-36 scales was observed, reaching statistical significance for physical functioning ( P = 0.03). Among patients who developed ED during the study, a deterioration in all SF-36 dimensions and a worsening in depressive symptoms preceded the development of ED. The onset of ED was associated with a further marked worsening in physical functioning ( P = 0.0008), general health perception ( P = 0.02), and social functioning ( P = 0.04) on SF-36 subscales, as well as in the summary physical and mental components scores ( P = 0.04 and P = 0.07, respectively). The development of ED was also associated with a highly significant increase in depressive symptoms ( P = 0.001) and a marked decrease in quality of sexual life ( P < 0.0001). CONCLUSIONS —This longitudinal study documents for the first time the impact of ED onset on several aspects of QoL in patients with type 2 diabetes. The study also shows that QoL tended to further decrease during 3 years in patients with ED at baseline but not in those without this condition. CES-D, Center for Epidemiologic Studies–Depression CVD, cardiovascular disease ED, erectile dysfunction QoL, quality of life TIBI, Total Illness Burden Index Footnotes * ↵ * A complete list of QuED Study Group investigators can be found in the appendix . A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. Accepted July 29, 2005. Received March 31, 2005. DIABETES CARE