Details

Autor(en) / Beteiligte

• Reis, José Diogo E
• Gomes, Paulo Wender P
• Sá, Paulo R. da C
• Pamplona, Sônia das G. S. R
• Silva, Consuelo Yumiko Y. e
• da Silva, Maria Fátima das G. F
• Bishayee, Anupam
• da Silva, Milton Nascimento

Titel

Putative Identification of New Phragmaline-Type Limonoids from the Leaves of ISwietenia macrophylla/I King: A Case Study Using Mass Spectrometry-Based Molecular Networking

Ist Teil von

• Molecules (Basel, Switzerland), 2023-11, Vol.28 (22)

Ort / Verlag

MDPI AG

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Swietenia macrophylla King is a plant commonly known as Brazilian mahogany. The wood from its stem is highly prized for its exceptional quality, while its leaves are valued for their high content of phragmalin-type limonoids, a subclass of compounds known for their significant biological activities, including antimalarial, antitumor, antiviral, and anti-inflammatory properties. In this context, twelve isolated limonoids from S. macrophylla leaves were employed as standards in mass spectrometry-based molecular networking to unveil new potential mass spectrometry signatures for phragmalin-type limonoids. Consequently, ultra-performance liquid chromatography coupled with high-resolution mass spectrometry was utilized for data acquisition. Subsequently, the obtained data were analyzed using the Global Natural Products Social Molecular Networking platform based on spectral similarity. In summary, this study identified 24 new putative phragmalin-type limonoids for the first time in S. macrophylla. These compounds may prove valuable in guiding future drug development efforts, leveraging the already established biological activities associated with limonoids.