Details

Autor(en) / Beteiligte

• Antipova, T. A.
• Deev, I. E.
• Gudasheva, T. A.
• Nikolaev, S. V.
• Logvinov, I. O.
• Serova, O. V.
• Gavrilenkova, A. A.
• Povarnina, P. Yu
• Tarasiuk, A. V.
• Vakhitova, Yu. V.
• Seredenin, S. B.

Titel

Evidence of Selective Interaction of Nerve Growth Factor Dipeptide Mimetic GK-2 with TrkA Receptor Using TrkA and TrkB Knockout HT-22 Cells

Ist Teil von

• Pharmaceutical chemistry journal, 2023-03, Vol.56 (12), p.1568-1572

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• TrkA and TrkB knockout HT-22 cell lines were used to prove that the neuroprotective properties of GK-2 [ bis ( N -monosuccinyl- L -glutamyl- L -lysine hexamethylenediamide], a low-molecular-weight dipeptide mimetic of the NGF 4 th loop, are definitely mediated by selective interaction with TrkA receptor upon oxidative stress-induced cellular damage in vitro .