Details

Autor(en) / Beteiligte

• Ga
• Ramidi, Punnamchandar
• Jones, Darin E
• Pulla, Sharon
• Ghosh, Anindya

Titel

Nickel complex catalyzed efficient activation of [sp.sup.3] and [sp.sup.2] C-H bonds for alkylation and arylation of oxygen containing heterocyclic molecules

Ist Teil von

• Catalysis letters, 2014-03, Vol.144 (3), p.507

Ort / Verlag

Springer

Erscheinungsjahr

2014

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• A nickel(II) complex (1)of N,N0-bis(2,6-diisopropylphenyl)-2,6-pyridinedicarboxamido (L) ligand was examined for catalytic coupling of Grignard reagents with the C-H bond of oxygen containing heterocyclic compounds such as tetrahydrofuran and furan. The nickel(II) complex showed excellent activity in catalyzing C-H activation and further coupling with various Grignard reagents. The effective activation of the C-H bond proceeded under ambient reaction conditions with a short reaction time (1-2 h). The catalyst (1) displays high turnover frequency of 4,130 [h.sup.-1] with catalyst loading as low as 0.01 mol%. This catalytic route could prove to be an efficient mode of activation of [sp.sup.3] and [sp.sup.2] C-H bonds in various heterocycles for the preparation of synthetically and pharmaceutically relevant molecules. Keywords Nickel(II) complex * Oxygen containing heterocyclics * Grignard reagents * [sp.sup.3] and [sp.sup.2] C-H bond activation