Details

Autor(en) / Beteiligte

• Weinhold, Niels
• Johnson, David C
• Chubb, Daniel
• Chen, Bowang
• Forsti, Asta
• Hosking, Fay J
• Broderick, Peter
• Ma, Yussanne P
• Dobbins, Sara E
• Hose, Dirk
• Walker, Brian A
• Davies, Faith E
• Kaiser, Martin F
• Li, Ni L
• Gregory, Walter A
• Jackson, Graham H
• Witzens-Harig, Mathias
• Neben, Kai
• Hoffmann, Per
• Nothen, Markus M
• Muhleisen, Thomas W
• Eisele, Lewin
• Ross, Fiona M
• Jauch, Anna
• Goldschmidt, Hartmut
• Houlston, Richard S
• Morgan, Gareth J
• Hemminki, Kari

Titel

The CCND1 c.870GA polymorphism is a risk factor for t multiple myeloma

Ist Teil von

• Nature genetics, 2013-05, Vol.45 (5), p.522

Ort / Verlag

Nature Publishing Group

Erscheinungsjahr

2013

Beschreibungen/Notizen

• A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyo-type. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x [10.sup.-11]). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.