Details

Autor(en) / Beteiligte

• Huang, Jing
• Pu, Xiao-Yan
• Cao, Xiang-Yun
• Fu, Jian
• Liu, Zheng

Titel

A 2-Fold Interpenetrating Zn(II)-MOF: Sensitive Detection of Fe.sup.3+ Ion and Anti-Cancer Activity on Breast Cancer Through high Intensity Focused Ultrasound

Ist Teil von

• Journal of inorganic and organometallic polymers and materials, 2021-05, Vol.31 (5), p.2209

Ort / Verlag

Springer

Erscheinungsjahr

2021

Quelle

SpringerNature Journals

Beschreibungen/Notizen

• Keywords: Zn(ii)-MOF; Luminescent sensor; Breast cancer; Molecular docking In the current study, via using a mixed ligand approach, a new three-dimensional metal--organic framework, [Zn.sub.2(L).sub.2(bpp)([H.sub.2]O).sub.2].sub.n (bpp=1,3-di(4-pyridyl)propane and [H.sub.2]L=2,5-thiophenedicarboxylic acid) was synthesized with a high yield under the condition of solvothermal reaction, and its structure was characterized through the diffraction of single crystal X-ray along with EA. Luminescence studies revealed that complex 1 can be utilized as the highly sensitive fluorescent sensor for sensing Fe.sup.3+ in aqueous solution. The apoptosis assay was used to assess the death of breast cancer cells after the compound treatment, and the relative expression of the genes related to ROS was also detected. The results for the simulation of molecular docking provided the novel design strategy of the anti-cancer drug and provided deeper insights into the anti-cancer activities. Author Affiliation: (1) Department of Ultrasound, Zhuhai People's Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, Guangdong, China (2) Department of Ultrasound, Suzhou Ninth People's Hospital, Suzhou, Jiangsu, China (3) The Second Department of General Surgery, Zhuhai People's Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, Guangdong, China (4) Medical Center, Wuhu First People's Hospital, Wuhu, Anhui, China (5) Department of Ultrasound, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu, China (e) fujian225588@163.com Article History: Registration Date: 01/27/2021 Received Date: 12/12/2020 Accepted Date: 01/27/2021 Online Date: 02/10/2021 Byline: