Details

Autor(en) / Beteiligte

• Barreto, Lidiane Carine Lima Santos
• Oliveira, Fernanda Santos
• Nunes, Paula Santos
• de França Costa, Iandra Maria Pinheiro
• Garcez, Catarina Andrade
• Goes, Gabriel Mattos
• Neves, Eduardo Luis Aquino
• de Souza Siqueira Quintans, Jullyana
• de Souza Araújo, Adriano Antunes

Titel

Epidemiologic Study of Charcot-Marie-Tooth Disease: A Systematic Review

Ist Teil von

• Neuroepidemiology, 2016-01, Vol.46 (3), p.157-165

Ort / Verlag

Basel, Switzerland: S. Karger AG

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. CMT is classified into 2 main subgroups: CMT type 1 (CMT1; demyelinating form) and CMT type 2 (CMT2; axonal form). The objectives of this study were to systematically review and assess the quality of studies reporting the incidence and/or prevalence of CMT worldwide. Summary: A total of 802 studies were initially identified, with only 12 meeting the inclusion criteria. CMT prevalence was reported in 10 studies and ranged from 9.7/100,000 in Serbia to 82.3/100,000 in Norway. The frequency of the main subtypes varied from 37.6 to 84% for CMT1 and from 12 to 35.9% for CMT2; the country with the lowest prevalence of CMT1 was Norway, and the country with the highest prevalence of CMT1 was Iceland; on the other hand, CMT2 was least prevalent in the United Kingdom and most prevalent in Norway. Key Messages: This review reveals the gaps that still exist in the epidemiological knowledge of CMT around the world. Published studies are of varying quality and utilise different methodologies, thus precluding a robust conclusion. Additional research focusing on epidemiological features of CMT in different nations and different ethnic groups is needed.