Details

Autor(en) / Beteiligte

• Srivastava , Neena
• Mittal , Balraj
• Srivastava , Apurva
• Prakash , Jai
• Awasthi , Shally

Titel

The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance

Ist Teil von

• Oman medical journal, 2018-09, Vol.33 (5), p.401-408

Ort / Verlag

Muscat - Oman: Oman Medical Specialty Board

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase ( ) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR). We examined the different gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. A substantial association was observed for -93 gene polymorphism of the gene with obesity, while -53 promoter gene polymorphism showed association with IR. We found a significant association between -93 and -53 promoter gene polymorphisms of the gene with obesity and associated phenotypes in the studied population.