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: In the present study, we examine the effects of copper oxide nanoparticles (CuNP) on macrophage immune response and the signaling pathways involved.
A peritonitis model was used to determine
immune cells recruitment, while primary macrophages were used as an
model for the cellular and molecular analysis.
, CuNP induce significant macrophages recruitment to the site of injection.
, in LPS-stimulated primary macrophages, the co-treatment with CuNP inhibited the production of NO in a dose-dependent manner. The mechanism underlying NO and proinflammatory cytokines inhibition was associated with an increased arginase activity. Macrophage stimulation with CuNP did not provoke any cytokine secretion; however, arginase inhibition promoted TNFα and MIP-1β production. In addition, CuNP induced the expression of COX-2 and the production of PGE
through arginase activation.
Our results demonstrate that CuNP activate arginase and suppress macrophage innate immune response.