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Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
Over the last two decades, tens of millions of dollars have been invested in understanding virulence in the human pathogen,
. However, the top 'hits' obtained in a recent TnSeq analysis aimed at identifying those genes that are conditionally essential for infection did not include most of the known virulence factors identified in these earlier studies. Instead, it seems that
faces metabolic challenges
, and unless it can overcome these, it fails to thrive and is cleared from the host. In this review, we look at the kinds of metabolic pathways that the pathogen seems to find essential, and comment on how this knowledge might be therapeutically exploited.