Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes, 1987-01, Vol.22 (5), p.553-564
1987
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Details
- Autor(en) / Beteiligte
- Titel
- Some metabolic changes induced by endosulfan in hepatic and extra hepatic tissues of rat
- Ist Teil von
- Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes, 1987-01, Vol.22 (5), p.553-564
- Ort / Verlag
- Philadelphia, PA: Taylor & Francis Group
- Erscheinungsjahr
- 1987
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Effects of three different doses of endosulfan respectively designated as low, medium and high on cytochrome P 450 (Cyt.P 450 ), glutathione S-transferase(GST) activity and glutathione content (GSH) of hepatic and extra hepatic tissues of rat were determined after 24 hours of treatment. Endosulfan caused induction of cyt. P 450 in liver, lung and brain at all the three doses tested while in kidney, spleen and heart either induction or reduction took place and was unrelated with dosages of endosulfan. Similarly, GST activity significantly changed in extra hepatic tissues while liver GST activity did not record any significant alteration under the experimental conditions. The GSH content also showed changes (increase/decrease) unrelated to endosulfan dosages in different organs. Thus, the effects varied with organ and dosages. As these metabolic parameters are involved in biotransformation of many endogenous molecules as well, the study may throw some light on physiological disturbances due to changes in metabolizing system on one side and organ specificity in toxic action of endosulfan on the other.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0360-1234eISSN: 1532-4109DOI: 10.1080/03601238709372572Titel-ID: cdi_fao_agris_US881113088
- Format
- –
- Schlagworte
- ACTIVIDAD ENZIMATICA, ACTIVITE ENZYMATIQUE, Administration, Oral, Animals, Biological and medical sciences, Brain - drug effects, Brain - enzymology, Brain - metabolism, Cytochrome P, Cytochrome P-450 Enzyme System - metabolism, CYTOCHROMES, Endosulfan, Endosulfan - administration & dosage, Endosulfan - pharmacology, ENZYMIC ACTIVITY, Female, FOIE, Glutathione, Glutathione - metabolism, Glutathione Transferase - metabolism, Glutathione-S-transíerase, Heart - drug effects, Hepatic and extrahepatic tissues, HIGADO, INSECTICIDAS, INSECTICIDE, INSECTICIDES, Kidney - drug effects, Kidney - enzymology, Kidney - metabolism, LIVER, Liver - drug effects, Liver - enzymology, Liver - metabolism, Lung - drug effects, Lung - enzymology, Lung - metabolism, Medical sciences, METABOLISM, METABOLISME, METABOLISMO, METALLOPROTEINE, METALLOPROTEINS, METALPROTEINAS, Myocardium - enzymology, Myocardium - metabolism, PEPTIDE, PEPTIDES, PEPTIDOS, PESTICIDE, PESTICIDES, Pesticides, fertilizers and other agrochemicals toxicology, PLAGUICIDAS, RAT, RATA, RATS, Rats, Inbred Strains, RESIDU, RESIDUES, RESIDUOS, Spectrophotometry, Spleen - drug effects, Spleen - enzymology, Spleen - metabolism, SUBSTANCE TOXIQUE, SUBSTANCIAS TOXICAS, thiodan, TOXIC SUBSTANCES, Toxicology