Details

Autor(en) / Beteiligte

• Sevanian, A
• Elsayed, N
• Hacker, A.D

Titel

Effects of vitamin E deficiency and nitrogen dioxide exposure on lung lipid peroxidation: use of lipid epoxides and malonaldehyde as measures of peroxidation [Alpha tocopherol, air pollution]

Ist Teil von

• Journal of toxicology and environmental health, 1982-10, Vol.10 (4/5), p.743-756

Ort / Verlag

United States: Taylor & Francis Group

Erscheinungsjahr

1982

Quelle

MEDLINE

Beschreibungen/Notizen

• The effect of vitamin E deficiency in male Sprague-Dawley rats upon lipid peroxidation in lung tissue was examined by measuring malonaldehyde and lipid epoxide production. In addition to controls, some animals were also exposed to 3 ± 0.7 ppm NO 2 continuously for 7 d in order to study the effects of oxidant stress on lung lipid peroxidation and vitamin E content. The observed changes in malonaldehyde and epoxide content could serve as good indices of lipid peroxidation, particularly under conditions of vitamin E deprivation. The responses measured indicated an inverse relation in the lung between tissue vitamin E content and quantity of lipid peroxidation products. Measurement of lipid epoxides served as a reliable indicator of lung tissue lipid peroxidation. Finally, NO 2 inhalation appeared to elicit a response characterized by increased assimilation of vitamin E into lung tissue.