Antimicrobial Agents and Chemotherapy, 2011-11, Vol.55 (11), p.5399-5402
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Functional Synergy between Antimicrobial Peptoids and Peptides against Gram-Negative Bacteria
- Ist Teil von
- Antimicrobial Agents and Chemotherapy, 2011-11, Vol.55 (11), p.5399-5402
- Ort / Verlag
- Washington, DC: American Society for Microbiology
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Antimicrobial peptides (AMPs) are integral components of innate immunity and are typically found in combinations in which they can synergize for broader-spectrum or more potent activity. Previously, we reported peptoid mimics of AMPs with potent and selective antimicrobial activity. Using checkerboard assays, we demonstrate that peptoids and AMPs can interact synergistically, with fractional inhibitory concentration indices as low as 0.16. These results strongly suggest that antimicrobial peptoids and peptides are functionally and mechanistically analogous.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4804eISSN: 1098-6596DOI: 10.1128/AAC.00578-11Titel-ID: cdi_fao_agris_US201500006468
- Format
- –
- Schlagworte
- amino acid derivatives, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antimicrobial Cationic Peptides, Antimicrobial Cationic Peptides - pharmacology, antimicrobial peptides, antimicrobial properties, Biological and medical sciences, Drug Synergism, Gram-Negative Bacteria, Gram-Negative Bacteria - drug effects, innate immunity, Medical sciences, Peptoids, Peptoids - pharmacology, Pharmacology. Drug treatments, Susceptibility, synergism