Details

Autor(en) / Beteiligte

• Liu, Yu
• Min, Danqing
• Bolton, Thyra
• Nubé, Vanessa
• Twigg, Stephen M
• Yue, Dennis K
• McLennan, Susan V

Titel

Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers

Ist Teil von

• Diabetes care, 2009, Vol.32 (1), p.117-119

Ort / Verlag

United States: American Diabetes Association

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• OBJECTIVE:--We studied the relationships of diabetic ulcer wound fluid matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and transforming growth factor-ss1 (TGF-ss1) with wound healing rate. RESEARCH DESIGN AND METHODS--The ulcers were cleansed to remove exudates, and wound fluids were collected for analysis of MMP-2 and -9, TIMP-1, and TGF-ss1. RESULTS:--At presentation, MMP-9 and the MMP-9-to-TIMP-1 ratio correlated inversely with the wound healing rate at 28 days (P < 0.001). MMP-9 and the MMP-9-to-TIMP-1 ratio were lower in the 23 patients who achieved complete healing at 12 weeks versus the 39 who did not. The pro-MMP-9 concentration was predictive of healing within 12 weeks. Addition of cutoffs for TIMP-1 (>480 pg/ml) and TGF-ss (>115 pg/ml) further improved its predictive power (area under the curve 0.94). CONCLUSIONS:--These findings suggest that a milieu with high MMP-9 may be indicative of inflammation and poor wound healing. Measurements of MMP-9, TIMP-1, and TGF-ss in wound fluid may help to identify ulcers at risk of poor healing.