Details

Autor(en) / Beteiligte

• Petrovová, E., University of Veterinary Medicine and Pharmacy in Košice (Slovak Republic)
• Maženský, D
• Danko, J

Titel

Using mesenchymal stem cells and biomaterials in hard tissue reconstruction

Ist Teil von

• Folia veterinaria, 2011, Vol.55 (1)

Erscheinungsjahr

2011

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Regenerative medicine is a new multidisciplinary area of medicine and offers new therapeutic methods for replacement or regeneration of the cells/tissues which are not functional due to disease, injury or congenital anomalies. It covers the methods of cell treatment and tissue engineering, and uses a range of new technological advances that provide benefits beyond simple traditional transplantations. Recently, the focus of attention has been concentrated upon implant preparation with mesenchymal stem cells seeded on a scaffold. Bone formation comprises a complex set of events that begins with the recruitment and proliferation of osteoprogenitors, followed by cell differentiation, osteoid formation, and mineralization. It has been recognized that bone is unique and has a vast potential for regeneration from stem cells. A number of reports have indicated there are a number of potential uses for mesenchymal stem cell transplantations from bone marrow in a variety of skeletal disorders. Mesenchymal stem cells have significance for veterinary medicine in basic theoretical disciplines, as well as for clinical use in large and small animal forms of regenerative applications, such as in the digestive and respiratory systems. The initial contact of the cells with the implant surface is of critical importance for adhesion of the bone cells that influence osseointegration. One strategy to improve osseointegration that has been tried involves the pre-coating of implants with an extracellular matrix protein for use as a scaffold, which enables specific cell-extracellular matrix interactions, along with the use of growth factors to facilitate the differentiation of the osteoblasts.