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Loss of the Expression and Localization of Inhibinα -Subunit in High Grade Prostate Cancer1
Ist Teil von
The journal of clinical endocrinology and metabolism, 1998-03, Vol.83 (3), p.969-975
Ort / Verlag
Endocrine Society
Erscheinungsjahr
1998
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
Serum inhibin levels are elevated in postmenopausal women with
granulosa and mucinous epithelial tumors of the ovary. In contrast,
functional deletion of the inhibin α gene in male and female mice
results in the development of primary gonadal granulosa/Sertoli cell
tumors. The aim of this study was to determine whether inhibinα
-subunit gene and protein expression are altered in prostate cancer.
Messenger ribonucleic acid expression was studied by in
situ hybridization, and protein localization was studied by
immunohistochemistry. Inhibin α-subunit messenger ribonucleic acid
expression and protein localization were observed in the epithelium of
tissues from men with benign prostatic hyperplasia, in regions of basal
cell hyperplasia, and in nonmalignant regions of tissue from men with
high grade prostate cancer. In the malignant regions of tissue from men
with high grade prostate cancer, the expression of the inhibinα
-subunit gene was suppressed and was not detectable in poorly
differentiated tumor cells. These results demonstrate that in contrast
to ovarian granulosa cell tumors, inhibin α gene expression is
down-regulated in poorly differentiated prostate cancer.