Details

Autor(en) / Beteiligte

• Marín, Carmen
• López-Miranda, José
• Gómez, Purificación
• Paz, Elier
• Pérez-Martínez, Pablo
• Fuentes, Francisco
• Jiménez-Perepérez, José Antonio
• Ordovás, José María
• Pérez-Jiménez, Francisco

Titel

Effects of the human apolipoprotein A-I promoter G-A mutation on postprandial lipoprotein metabolism123

Ist Teil von

• The American journal of clinical nutrition, 2002-08, Vol.76 (2), p.319-325

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2002

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• There is considerable interindividual variability in the postprandial lipid response to a fat-rich meal, and genetic factors have been considered to account for some of these effects. We previously showed that the G-A mutation 5′ to the apolipoprotein (apo) A-I gene was significantly associated with the LDL-cholesterol response to diet. We evaluated whether this effect is mediated by mechanisms involving postprandial lipoprotein metabolism. Twenty-eight G/G and 23 G/A healthy male subjects, homozygotes for the apo E3 allele, were subjected to a vitamin A fat-loading test. Blood was drawn at time 0 and every hour for 11 h. There was a significant postprandial decrease in plasma cholesterol, LDL cholesterol, and apo B in G/G subjects but not in G/A subjects. A greater postprandial response in large triacylglycerol-rich lipoproteins (TRLs) and a smaller postprandial response in large TRL apo A-IV was observed in G/A than in G/G subjects. Retinyl palmitate in large and small TRL concentrations was similar for both genotypes. No significant genotype effects were detected for triacylglycerol concentrations in plasma, small TRL fraction, and apo A-I and HDL-cholesterol concentrations. Our data suggest that the G-A mutation affects the LDL-cholesterol response to diet by mechanisms involving postprandial lipoprotein cholesterol metabolism.